Drug Standards
Medchemexpress LLC Lenalidomide-propargyl-C2-NH2 (hydrochloride) | 2489242-23-9 | 98.0% | 25 MG
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. It can be utilized in the design of PROTAC MD-224. As a click chemistry reagent, Lenalidomide-propargyl-C2-NH2 (hydrochloride) contains an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess Azide groups.
- Incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker.
- Can be used to design the PROTAC MD-224.
- Contains an Alkyne group for click chemistry.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess Azide groups.
Medchemexpress LLC Fostamatinib | 901119-35-5 | 99.7% | 25 MG
Fostamatinib is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor. It also inhibits Lyn and Lck, playing a role in various cellular pathways. This product is a solid form of Fostamatinib with high purity, suitable for laboratory research.
- Oral proagent of active compound R406
- Competitive Syk/FLT3 inhibitor
- Also inhibits Lyn and Lck
- High purity of 99.7%
- Recommended storage for powder at -20°C for 3 years or 4°C for 2 years
- Recommended storage for in-solvent at -80°C for 1 year or -20°C for 6 months
- Shipped at room temperature for less than 2 weeks
Medchemexpress LLC Ivermectin B1a | 71827-03-7 | 100.0% | 1 ML
Ivermectin B1a is a main component of Ivermectin and a derivative of Avermectin B1a. It functions as a broad-spectrum anti-parasite agent and is a candidate therapeutic against SARS-CoV-2/COVID-19. This compound belongs to the macrocyclic lactone class of avermectins.
- Functions as a broad-spectrum anti-parasite agent.
- Main component of Ivermectin.
- Identified as a candidate therapeutic against SARS-CoV-2/COVID-19.
- Belongs to the macrocyclic lactone class of avermectins.
- Purity of 99.97%.
- Available as a 10 mM solution in DMSO.
Medchemexpress LLC Diclofenac ethyl ester | 15307-77-4 | 99.3% | 1 ML
Diclofenac ethyl ester is the prodrug of Diclofenac. It is encapsulated in polymer micelles in vitro and released with prolonged circulation time, leading to reduced drug concentrations in the heart and kidneys in vivo.
- Prodrug of Diclofenac
- Encapsulated in polymer micelles in vitro
- Released with prolonged circulation time
- Reduces drug concentrations in the heart and kidneys in vivo
- For research use only
Medchemexpress LLC Naphazoline | 835-31-4 | 99.7% | 210.27 | 50 MG
Naphazoline is a potent α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. It can be used for non-bacterial conjunctivitis research.
- Reduces vascular hyperpermeability.
- Promotes vasoconstriction.
- Reduces inflammatory factors.
- Reduces cytokines.
- Reduces IgE, GMCSF, and NGF.
- Suitable for non-bacterial conjunctivitis research.
Medchemexpress LLC Risperidone | 106266-06-2 | MFCD00274576 | 99.9% | 410.5 g/mol | 100 MG
Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. It is for research use only.
- Serotonin 5-HT2 receptor blocker
- P-Glycoprotein inhibitor
- Potent dopamine D2 receptor antagonist
- For research use only
Medchemexpress LLC Gemcitabine monophosphate | 116371-67-6 | 100.0% | 343.18 | 100 MG
Gemcitabine monophosphate is an active intermediate of Gemcitabine. It demonstrates a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles. It is intended for research use only.
- Active intermediate of Gemcitabine.
- Demonstrates synergistic anti-cancer effect.
- Can be delivered by formulating it into nanoparticles.
- Exhibits anti-small cell lung cancer activity in animal models.
- Induces tumor cell apoptosis.
- Reduces tumor cell proliferation.
- Inhibits tumor mitosis.
- Suitable for laboratory research.
Medchemexpress LLC Tenofovir exalidex | 911208-73-6 | 99.8% | 569.72 | 100 MG
Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir. It is active against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. It is effective against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available, has no apparent toxicity, and also shows antiviral activity against HBV.
- Consistently >300-fold more active than Tenofovir against multiple viruses
- Effective against MNR mutants unresponsive to currently available NRTIs
- Inhibits HBV polymerase-mediated HBV DNA elongation
Medchemexpress LLC Ciprofloxacin-d8 (hydrochloride) | 1216659-54-9 | 98.8% | 5 MG
Ciprofloxacin-d8 (hydrochloride) is a deuterium labeled fluoroquinolone antibiotic, exhibiting potent antibacterial activity. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development, and deuteration can affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits potent antibacterial activity
Medchemexpress LLC Carbidopa ((S)-(-)-Carbidopa) | 28860-95-9 | 99.8% | 50 MG
Carbidopa ((S)-(-)-Carbidopa) is a peripheral decarboxylase inhibitor that can be utilized for Parkinson's disease research. It acts as a selective aryl hydrocarbon receptor (AhR) modulator and has been shown to inhibit pancreatic cancer cell and tumor growth.
- Peripheral decarboxylase inhibitor.
- Used in Parkinson's disease research.
- Selective aryl hydrocarbon receptor (AhR) modulator.
- Inhibits pancreatic cancer cell and tumor growth.
Medchemexpress LLC Idoxuridine | 54-42-2 | 99.8% | 1 ML
Idoxuridine is an iodinated thymidine analogue that acts as a competitive inhibitor of phosphorylases. It inhibits viral activity, particularly viral eye infections like herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. It demonstrates an IC50 value of 4.3 μM against feline herpesvirus and shows anti-orthopoxvirus activity.
- Inhibits viral activity
- Acts as a competitive inhibitor of phosphorylases
- Inhibits DNA polymerase
- Affects viral replication
- Shows anti-orthopoxvirus activity
Medchemexpress LLC Hydrochlorothiazide (Standard) | 58-93-5 | 99.5% | 1 MG
Hydrochlorothiazide (HCTZ) is an orally active thiazide diuretic that inhibits the transforming TGF-β/Smad signaling pathway. It also directly relaxes blood vessels by opening calcium-activated potassium channels. This compound improves cardiac function, reduces fibrosis, and has antihypertensive effects.
- Orally active diuretic.
- Inhibits TGF-β/Smad signaling pathway.
- Causes direct vascular relaxation by opening KCA channels.
- Improves cardiac function and reduces fibrosis.
- Possesses antihypertensive effects.
Medchemexpress LLC Cpd-39 | 3055472-38-0 | 98.1% | 10 MG
CPD-39 is a heterobifunctional PROTAC degrader that targets CCND1 and CDK4 and shows orally active anti-proliferative activity in preclinical studies. It is provided as a high-purity research reagent for laboratory investigations into targeted protein degradation and cell proliferation mechanisms.
- Targets CCND1 and CDK4 for proteasomal degradation.
- Demonstrates orally active anti-proliferative activity in preclinical models.
- High purity, suitable for analytical and biological research.
- Supplied in milligram-scale quantities for laboratory experiments.
- Intended for research use only; not for human or diagnostic applications.
Medchemexpress LLC Dabigatran etexilate impurity 3 | 1416446-43-9 | 5mg
Dabigatran impurity 3 is an impurity of Dabigatran (HY-10163)
U.S. Pharmacopeia Loratadine Related Compound A | 100643-71-8 | MFCD00871949 | 15mg
Loratadine Related Compound A | Mol Wt: 310.826 | 100643-71-8 | MFCD00871949 | 15mg
